Simulation of Gene Regulatory Networks

ثبت نشده
چکیده

I have been assisting Professor Jacques Cohen at Brandeis University to explore and compare the the many available representations and interpretations of genetic regulatory networks. The term regulatory network usually refers to the complex system of interactions that controls gene transcription and translation. A simplified description of the transcription-translation process is as follows: First, RNA polymerase attaches to a promoter site on a gene and produces an mRNA mirror of the gene’s DNA sequence. Next, a ribosome translates a protein product from the strand of mRNA. At either step in this process proteins and other chemical and physical factors in the cell’s environment can interfere to either promote or suppress the production of a protein from its source gene.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

H∞ Sampled-Data Controller Design for Stochastic Genetic Regulatory Networks

Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...

متن کامل

Modeling gene regulatory networks: Classical models, optimal perturbation for identification of network

Deep understanding of molecular biology has allowed emergence of new technologies like DNA decryption.  On the other hand, advancements of molecular biology have made manipulation of genetic systems simpler than ever; this promises extraordinary progress in biological, medical and biotechnological applications.  This is not an unrealistic goal since genes which are regulated by gene regulatory ...

متن کامل

Improving the Inference of Gene Expression Regulatory Networks with Data Aggregation Approach

Introduction: The major issue for the future of bioinformatics is the design of tools to determine the functions and all products of single-cell genes. This requires the integration of different biological disciplines as well as sophisticated mathematical and statistical tools. This study revealed that data mining techniques can be used to develop models for diagnosing high-risk or low-risk lif...

متن کامل

Improving the Inference of Gene Expression Regulatory Networks with Data Aggregation Approach

Introduction: The major issue for the future of bioinformatics is the design of tools to determine the functions and all products of single-cell genes. This requires the integration of different biological disciplines as well as sophisticated mathematical and statistical tools. This study revealed that data mining techniques can be used to develop models for diagnosing high-risk or low-risk lif...

متن کامل

The Role of Regulatory in Price Control and Spectrum Allocation to Competing Wireless Access Networks

With the rapid growth of wireless access networks, various providers offer their services using different technologies such as Wi-Fi, Wimax, 3G, 4G and so on. These networks compete for the scarce wireless spectrum. The spectrum is considered to be a scarce resource moderated by the spectrum allocation regulatory (“regulatory” for short) which is the governance body aiming to maximize the socia...

متن کامل

Comparison of MLP NN Approach with PCA and ICA for Extraction of Hidden Regulatory Signals in Biological Networks

The biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. So far, many computational and statistical methods such as PCA and ICA have been employed for computing low-dimensional or hidden represe...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005